Wolfhounds can get the same illnesses as any other dog. Their fast rate of growth from puppyhood places strain on their skeleton and bone cancer in the legs is unfortunately quite common but can be treated if diagnosed early enough. The cause of any limping should be carefully established.
As wolfhounds reach great age the nerves in their spine tend to degenerate and they lose control of their rear legs. Acupuncture can relieve this condition. Before any surgery you should check that the vet is aware that wolfhounds require less anaesthetic per unit weight than other dogs.
This is a problem experienced by all sighthounds stemming from their fat to muscle ratio which affects the removal of the drug from their systems.
An excellent source of issues affecting wolfhound health is the Irish Wolfhound Health Group based in the UK.