In general, yes. However, Irish Wolfhounds are predators and have a predator’ s instinctive attitude towards potential prey and prey-species. The intensity of the prey instinct varies from individual to individual. Small animals, including cats and small dogs, that move rapidly may bring out the prey instinct.
If you want to keep a Wolfhound with small dogs or cats they need to be exposed to these animals from a young age and learn that chasing is not allowed.